Associate Professor of Pediatrics, Harvard Medical School
Anne Hansen received her MD from Harvard Medical School and her MPH from Harvard School of Public Health with a concentration in Clinical Effectiveness. She completed pediatric residency at Children’s Hospital Boston and fellowship in Newborn Medicine at Children’s Hospital Boston, Beth Israel Hospital and Brigham and Women’s Hospital. Dr. Hansen joined the Harvard Medical School faculty in 1996 and is currently an Associate Professor of Pediatrics. Dr. Hansen has acted as Chair of the Harvard¬wide Neonatal Research Review Committee since 2004, and as Neonatology Consultant for the Rwinkwavu, Kirehe and Butaro Hospitals in Rwanda since 2010. She is a member of multiple committees, including the Boston Children’s Hospital Steering Committee (Medical chair), the Harvard Neonatal¬-Perinatal Medicine Training Program Fellowship Committee, the NICU Nutrition Committee, and the Neonatology Representative for the Advanced Fetal Care Center at Children’s Hospital Boston. She is also a Fellow in the American Academy of Pediatrics. Dr. Hansen has been nominated for the Harvard Medical School Prize for Excellence in Teaching twice, the Harvard Medical School Humanism in Medicine Award, and was awarded the Best Tutor of the Year Harvard Medical School Teaching Award.
Dr. Hansen’s research focuses on improving the care of newborns seriously ill with medical and surgical conditions as well as those in resource limited settings. For medical patients, she is collaborating with engineers and industry to develop a Central Venous Catheter with decreased propensity for infection or clot formation have examined innovative approaches to the treatment of neonatal conditions including intraventricular urokinase for the prevention of posthemorrhagic hydrocephalus, once daily gentamicin dosing for infants, substitution of cord for infant blood in peri¬natal sepsis evaluations, and inhaled racemic epinephrine for the treatments of TTN. Dr, Hansen developed and implemented the first therapeutic hypothermia program in New England. She is a coeditor of the Manual of Neonatal Care, now in its 8th edition. For surgical patients, she is collaborating with a BCH based surgeon to develop a novel, minimally invasive approach to esophageal growth induction for patients with long gap esophageal atresia. Dr. Hansen was lead investigator in a study of Donation after Cardiac Death (DCD) in the NICU. She is co¬editor of the Manual of Neonatal Surgical Intensive care, now in its 3rd edition.
Using her experiences from the CHB NICU, Dr. Hansen is working on several neonatology projects for the resource limited setting. In collaboration with the Lawrence Berkeley National Laboratory Institute for Globally Transformative Technologies, she is developing an inexpensive nonelectric infant warmer that has been tested successfully in Rwanda and are now working to scale nationally and internationally. In partnership with the Rwandan Ministry of Health (MOH), she helped to develop and implement a package of newborn medicine materials for Rwanda that was accepted as the national standard for neonatal care. They have written the 2nd edition and conducted national trainings with nurses and doctors from all Rwandan provincial hospitals. They are now working to produce videos of these trainings, taught by Rwandan doctors and nurses through OPENPediatrics, a web-based, open access learning platform supported by Boston Children’s Hospital with a goal to provide high-quality video education to pediatricians around the world.
Publications powered by Harvard Catalyst Profiles
- Angelidou A, Bell K, Gupta M, Tropea Leeman K, Hansen A. Implementation of a Guideline to Decrease Use of Acid-Suppressing Medications in the NICU. Pediatrics. 2017 Dec; 140(6).
- Twichell SA, Fiascone J, Gupta M, Prendergast M, Rodig N, Hansen A. A Regional Evaluation of Survival of Infants with End-Stage Renal Disease. Neonatology. 2017; 112(1):73-79.
- ) Hansen A, Magge H, Labrecque M, Munyanez R, Nahimana E, Nyishime M, Mwali A. The Development and Implementation of a Newborn Medicine Program in a Resource Limited Setting . Public Health Action. 2015.
- Leslie DC, Waterhouse A, Berthet JB, Valentin TM, Watters AL, Jain A, Kim P, Hatton BD, Nedder A, Donovan K, Super EH, Howell C, Johnson CP, Vu TL, Bolgen DE, Rifai S, Hansen AR, Aizenberg M, Super M, Aizenberg J, Ingber DE. A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nat Biotechnol. 2014 Nov; 32(11):1134-40.
- Gupta M, Ringer S, Tess A, Hansen A, Zupancic J. Developing a quality and safety curriculum for fellows: lessons learned from a neonatology fellowship program. Acad Pediatr. 2014 Jan-Feb; 14(1):47-53.
- Touma M, Joshi M, Connolly MC, Grant PE, Hansen AR, Khwaja O, Berry GT, Kinney HC, Poduri A, Agrawal PB. Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. Epilepsia. 2013 May; 54(5):e81-5.
- Wintermark P, Boyd T, Gregas MC, Labrecque M, Hansen A. Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia. Am J Obstet Gynecol. 2010 Dec; 203(6):579.e1-9.
- Wintermark P, Labrecque M, Warfield SK, DeHart S, Hansen A. Can induced hypothermia be assured during brain MRI in neonates with hypoxic-ischemic encephalopathy? Pediatr Radiol. 2010 Dec; 40(12):1950-4.
- Labrecque M, Parad R, Gupta M, Hansen A. Donation after cardiac death: the potential contribution of an infant organ donor population. J Pediatr. 2011 Jan; 158(1):31-6.
- Meyer EC, Brodsky D, Hansen AR, Lamiani G, Sellers DE, Browning DM. An interdisciplinary, family-focused approach to relational learning in neonatal intensive care. J Perinatol. 2011 Mar; 31(3):212-9.
- Anne Hansen was born on December 4, 2017 at Berkeley California.
Education and Training
- Dr. Anne Hansen MD, MPH received her MD from Harvard Medical School and her MPH from Harvard School of Public Health in Boston MA, with concentration in Clinical Effectiveness.
- Dr. Hansen completed pediatric residency at the Children’s Hospital, Boston MA, and fellowship in Newborn Medicine at Children’s Hospital, Beth Israel and Brigham and Women’s Hospital in Boston, MA.
Faculty Academic Appointments
- Hansen joined the Harvard Medical School faculty in 1996 and is currently an Associate Professor of Pediatrics, and an Affiliate of the Department of Global Health and Social Medicine
License, Certification, Clinical Activities and Affiliated Institutions
- Hansen is a licensed member of the American Board of Pediatrics with certification in Neonatology/Perinatology. Since 1996, she has been practicing Level III NICU at the Children’s Hospital Boston and at the Beth Israel Deaconess Medical Center. Prior to that, she practiced Level II Special Care Nursery at the Metrowest Medical Center.
- As a Neonatologist, Dr. Hansen is affiliated with multiple hospitals in Massachusetts including the Winchester Hospital, Children’s Hospital, Beth Israel, Brigham and Women’s Hospital, and Beverly Hospital, and South Shore Hospital. Dr. Hansen is also a fellow of the American Academy of Pediatrics.
Other Professional Positions
- As an International Health Worker, Dr. Hansen worked at the Harare and Nyangan Hospital in Zimbabwe in 1989, and acted as a Neonatology Consultant at the Rwinkwavu, Kirehe and Butaro Hospitals in Rwanda since 2010.
Major Administrative Leadership Positions
- Hansen has held several leadership positions including being Director of Community Neonatology (2001-2015) at the Children’s Hospital, and Clinical Course Director of the Neonatal Medicine rotation (2002-2006) at the Harvard Medical School. She was also the Director of Neonatology of the Metrowest Medical Center in Framingham, MA from 2000-2002.
- At present, Dr. Hansen is the Medical Director of the Neonatal Intensive Care Unit, and Supervising Physician of Neonatal Nurse Practitioners of the Children’s Hospital, and chairs the Harvard-wide Neonatal Research Review Committee, of which she has been a member since its inception in 2002.
Local Teaching and Training
- As an Associate Professor, Dr. Hansen taught medical students taught Introduction to Clinical Medicine, Physiology, and Patient/Doctor II, at the Harvard Medical School.
- Hansen also facilitated formal teaching of residents, clinical fellows, and research fellows in Transport Medicine, and Surgery and Neonatology Cross-Over lectures at the Children’s Hospital Boston. She is currently conducting lectures on Intraventricular Hemorrhage and Periventricular Leukomalacia to Pediatric Interns at the Brigham and Women’s Hospital, Boston.
- In 2005, she developed the course curriculum for the Program to Enhance Relational and Communication Skills (PERCS) for Neonatology trainees and multidisciplinary NICU staff at the Children’s Hospital Boston, of which she is also the Course Director.
- Hansen has supervised a number of trainings at the Children’s Hospital, including Pediatric Advanced Certification Life Support, and Introduction to Neonatology and the NICU for Respiratory Therapists. At present, she is teaching responsibilities for neonatal fellows, residents, interns, medical students and nurse practitioners in the NICU.
- Hansen formally supervised Michele Ambrosino and Mary Quinn, Neonatal Nurse Practitioners, of Beth Israel Deaconess Medical Center in writing and editing chapters for the Manual of Neonatal Mock Codes that was published in 2006. She was also the mentor of Rajiv Beveja, MD, Yolanda Brown MD, Sarah Stewart de Ramirez MPH MSc, HMS III Pia Wintermark, MD, Donna Brezinski MD.
- At present, Dr. Hansen is a member of the scholarship oversight committee and mentor of Dr. Leana May DO, MPH, Assistant Professor of Pediatrics at the Children’s Hospital in Colorado and University of Colorado School of Medicine, in her research regarding non-electric infant warmers; and of Dr. Paulina Ortiz-Rubio, Assistant Professor of Pediatrics, Uniformed Services University of the Health Sciences, and Staff Pediatric Endocrinologist at the Naval Medical Center San Diego on her research on the efficacy of continuous glucose monitoring in neonates.
- Hansen is an active member of multiple committees including Boston Children’s Hospital Steering Committee (Medical chair), the Harvard Neonatal-Perinatal Medicine Training Program Fellowship Committee, the NICU Nutrition Committee, and the Neonatology Representative for the Advanced Fetal Care Center at Children’s Hospital Boston. She is also the founder and medical chair of the Family Advisory Council.
Awards and Recognitions
- Throughout her career, Dr. Hansen has received many awards and distinctions including the Merton Bernfield Award in Mentoring, winner of the Saving Lives at Birth Peer Choice Award in 2017, and Harvard Medical School’s Teaching Award for Best Tutor of the Year in 2004. She was nominated for the Harvard Medical School Prize for Excellence in Teaching twice, and the Harvard Medical School Humanism in Medicine Award.
Review, Editorial Activities and Publications
- Hansen is an Ad hoc member of the CIMIT Primary Care Prize, and an Ad hoc reviewer for Pediatrics and Circulation, Journal of Pediatrics and Child Health, and American Journal of Perinatology. She has authored or co-authored 30 research investigations, including 4 in the American Journal of Perinatology, 3 in the American Journal of Pediatrics, and 2 in the American Journal of Obstetrics and Gynecology.
- Hansen has authored or co-authored 53 chapters/reviews/editorials, including 25 chapters of The Manual of Surgical Neonatal Intensive Care, and 8 chapters of The Manual for Neonatal Care.
- Hansen has authored or co-authored 9 books and textbooks including eight editions of “The Manual of Neonatal Care”, and 3 editions of “The Manual of Surgical Neonatal Intensive Care”.
- Hansen has written 22 clinical guidelines and reports. 4 of which have been disseminated for publication in manuals and 2 have been disseminated to local Boston NICUs at BIDMC, BWH, MGH, St. Elizabeth’s Hospital, South Shore Hospital.
- 5 health articles published in the Parent Magazine, Good Housekeeping, Boston Children’s Hospital’s Notes blog, and CNN were sourced from Dr. Hansen’s studies and expertise.
- Since 2001, Dr. Hansen has had 21 interviews by major publications and tv stations, including The Boston Herald, Boston Globe, Voice of America, Pregnancy Magazine, Fit Magazine, CNS, CNN, CBS 4 and WCVB Channel 5. In 2013, she was interviewed and filmed for the movie “Giving” about Dr. Chris Hansen.
- In 2005, Dr. Hansen, in collaboration with a social worker, psychologist and a family of a year old sibling of Children’s Hospital Boston NICU patient, wrote an illustrated book “My Bruthr Timothy” intended to help parents support the siblings of a sick newborn.
Events & Presentations
- As a pediatric and neonatology expert, Dr. Hansen has been invited to present at numerous events both locally and internationally, including the Morbidity and Mortality Conference, Advanced Fetal Care Center National Conference, Obstetric, Surgery and Pediatric Grand Rounds, Harvard University’s Neonatal Health Initiative, and the recent Global Health Forum, among many others.
- On a national level, Dr. Hansen and her team’s study on the “Implementation of an evidence-based guideline to reduce unnecessary antacid use in the NICU”, was presented at the CHND Annual Meeting in Kansas MO, Pediatrics Academic Societies Annual Meeting, in San Francisco CA, and at the American Academy of Pediatrics (AAP) National Conference & Exhibition in Chicago, IL, where it received the AAP 2017 Young Investigator Award for the Section on Neonatal Perinatal Medicine.
- Dr. Hansen recently presented her work on the Non-Electric Infant Warmer at the Saving Lives at Birth Development Change event in Washington DC, and at the ICV Investing in African Health Systems, in New York, NY.
- Internationally, Dr. Hansen has been invited to present her studies on numerous occasions in several countries including, Ecuador, Dominican Republic, Colombia, Argentina, and Rwanda. She was the course director of the 2017 OPEN Pediatrics: Rwandan Newborn Care Protocols in Rwinkwavu, Rwanda.
- Hansen has conducted 18 exhibits and presentations at several professional meetings including one in San Francisco, CA, where their oral presentation on the Implementation of an evidence-based guideline to reduce unnecessary antacid use in the NICU was voted best abstract/platform presentation by the National APA Meeting. The Prospective Study of Low Cost, Electricity-Free Infant Warmer, was voted as the best innovative presentation by the Rwanda Pediatric Association
Studies and Innovation
- As a medical innovator of the NICU, Dr. Hansen has been involved in all innovations in the NICU since 2003 in a number of areas including:
- Innovations in Clinical Care and Quality Improvement, Children’s Hospital Boston – Dr. Hansen has been either a primary author or a significant contributor to numerous policies and practice guidelines regarding the care of medical and surgical NICU patients. As a recent example of an innovation in clinical care, Dr. Hansen spearheaded the effort to decrease unnecessary antacid use in the NICU, one of the 5 overused practices in the Choosing Wisely campaign. She helped write a guideline with a narrow list of indicated used based on literature review and expert opinion, formed a QI work-group to implement this guideline and presented this work via abstracts and posters at multiple national meetings.
- Neuroprotection, Children’s Hospital Boston – Since 2007, Dr. Hansen has been involved in a comprehensive neuroprotection program in the NICU that consists of therapeutic hypothermia, research on antiepileptic medications and neuroimaging. She developed and implemented a protocol and database to be the first site in New England to offer Therapeutic Hypothermia TH) for newborns with hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia. They have since shared our protocol for use with 6 other tertiary centers in New England. I serve as a lead participant in an ongoing CRICO effort to standardize and educate providers’ use of TH. She is an investigator ona pharmacokinetic study of Bumetanide as an antiepileptic for newborns with HIE and have worked closely with Dr Grant to develop her Neuroimaging service including sophisticated MRI and Near Infrared Spectroscopy testing.
- Global Newborn Medicine, Rwanda – In 2010, Dr. Hansen was funded by the Milton Foundation to develop and implement a comprehensive Newborn Medicine Program in Rwinkwavu, a rural village in Rwanda, where she provided on-site courses and clinical training from June – August 2010. Their package of protocols, medical records, teaching materials and quality indicators were presented to and accepted by the Ministry of Health as national standards in neonatology. She and her team then developed and introduced a CPAP guideline, rewrote a 2nd edition of the National Neonatal Guidelines to include CPAP and other enhancements, developed and taught a national training on the 2nd edition guidelines, and are now in the process of creating an OPEN Pediatrics course covering these national trainings; and,
- Non-Invasive Pain Assessment – In 2016, Dr. Hansen began collaborating with anesthesiologists and neuroimaging experts to study non-invasive approaches to the assessment of pain in NICU patients, and developed a package of potential approaches including EEG, EMG, skin conductance and subdermal blood flow. She and her team piloting its use to assess pain in control and post-operative patients including those requiring chemical paralysis.
- Hansen collaborated with the Lawrence Berkeley National Laboratory Institute for Globally Transformative Technologies (LIGTT) to develop a low cost, re-usable, non-electric infant warmer made of phase change materials that changes from liquid to solid at skin temperature. The warmer was tested in the hospital setting in Rwanda with excellent results that have been submitted for publication. Patients are now being enrolled in the clinic and transport setting. The Non-electric Infant Warmer is a finalist in a Saving Lives at Birth grant to validate warmer use in 25% of all provincial hospitals in Rwanda with a long term goal of global scale up.
- Hansen collaborated with the Wyss Foundation and the department of surgery to develop a device for Hydrostatic Intraluminal Esophageal Stretch, a non-invasive device for treatment of Long Gap Esophageal Atresia. The results for animal model testing have been published and the next step is to identify a manufacturer to produce GMP quality devices for human use.
- Since 1994, Dr. Hansen’s projects have been supported by several organizations in terms of funding, including grants from the Children’s Hospital, Wyss Institute, and the NIH Research Project Grant Program (NIH R01). Her current project on the “Assessment for Application of Slippery Surface to decrease Central Line Associated Bloodstream Infections” recently received the Innovation Acceleration Program (IAP) Accelerator Grant.